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Determination of Histamine in Rat Plasma and Tissue Extracts by Intramolecular Excimer-Forming Derivatization and LC with Fluorescence Detection

✍ Scribed by Fumio Ichinose; Takashi Yoshitake; Hideyuki Yoshida; Kenichiro Todoroki; Jan Kehr; Osamu Inoue; Hitoshi Nohta; Masatoshi Yamaguchi


Book ID
111791622
Publisher
Springer
Year
2009
Tongue
English
Weight
443 KB
Volume
70
Category
Article
ISSN
0009-5893

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## Abstract A rapid and sensitive HPLC enantioselective method with fluorescence detection was developed to determine (βˆ’)‐(__R__) and (+)‐(__S__) enantiomers of the metabolites of citalopram, demethyl‐ and didemethyl‐citalopram in plasma and brain tissue. This assay involves pre‐column chiral deriv