Determination of grandiflorenic acid in organic and aqueous extracts of Montanoa tomentosa (zoapatle) by reversed-phase high-performance liquid chromatography

✍ Scribed by R.G. Enríquez; L.I. Escobar; M.L. Romero; M.A. Chávez; X. Lozoya

• Book ID: 104144893
• Publisher: Elsevier Science
• Year: 1983
• Tongue: English
• Weight: 319 KB
• Volume: 258
• Category: Article
• ISSN: 1873-3778
• DOI: 10.1016/s0021-9673(00)96430-6

✦ Synopsis

Montanoa tomentosa Cerv. (popularly known as "zoapatle") is a shrub widely distributed in Mexico that has been known since prehispanic times for its reputation in facilitating labour and its potential as a terminator of pregnancylm4.

A chemical-biological examination of a hexane extract of zoapatle leaves was recently undertaken as it possesses uterotonic effect ipl viva and in vitro animal studies. Fractionation of this extract by column chromatography and ipl vitro pharmacological assay allowed a correlation to be shown between those fractions containing grandiflorenic acid (GA) (I) and an uteroconstrictive biological effect5. As with a hexane extract of the roots6, GA is found to be associated in the corresponding extract of leaves with other closely related diterpenic acids, e.g., kaurenoic (KA) (II) and monoginoic (MA) (III). The latter are under pharmacological investigation since they also possess uterotropic effect7.