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Determination of gestational opiate, nicotine, benzodiazepine, cocaine and amphetamine exposure by hair analysis

✍ Scribed by P. Kintz; P. Mangin


Publisher
Elsevier
Year
1993
Tongue
English
Weight
397 KB
Volume
33
Category
Article
ISSN
0015-7368

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Evidence of gestational heroin or nicoti
✍ Pascal Kintz; Patrice Mangin 📂 Article 📅 1993 🏛 Elsevier Science 🌐 English ⚖ 414 KB

Failure to identify tobacco- or heroin-exposed neonates is extensive owing to the limitations of current methods used to verify maternal drug use. Maternal self-reported drug history has been shown to be unreliable: many women who deny use during pregnancy exhibit drug metabolites in their urine. Ma

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## Abstract A simple liquid chromatography–electrospray ionization mass spectrometry (LC‐ESI‐MS) method for the determination of nicotine and cotinine in human hair was established. In the procedure, a hair sample (10 mg) was washed with dichloromethane and digested in 2.5 m sodium hydroxide. The d