Determination of fragment D-dimer derivatives in serum reactive with antiserum against human fragment D-dimer

✍ Scribed by Matsushima, A. ;Shimizu, A. ;Takahama, Y. ;Tsukada, T. ;Inada, Y.

• Book ID: 104740657
• Publisher: Springer-Verlag
• Year: 1984
• Weight: 280 KB
• Volume: 49
• Category: Article
• ISSN: 1432-0584
• DOI: 10.1007/bf00363701

✦ Synopsis

A previous study demonstrated the preparation of an antiserum having enough specificity and sensitivity for a radioimmunoassay to determine fragment D-dimer derivatives. Using the antiserum the contents of fragment D-dimer derivatives in the sera of normal subjects and patients were determined. The content in normal subjects was 0.260 +/- 0.07 micrograms/ml (mean +/- SD) an that in patients with elevated levels of FDP ranged from 0.30 to 28 micrograms/ml. The values of fragment D-dimer derivatives and FDP in sera of some patients did not necessarily change in parallel, although there seems to be generally a positive correlation between them.