Determination of fluorinated hydrocarbon propellants in blood of dogs after aerosol administration

✍ Scribed by Leon Shargel; Raymond Koss

• Book ID: 102402402
• Publisher: John Wiley and Sons
• Year: 1972
• Tongue: English
• Weight: 402 KB
• Volume: 61
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600610920

✦ Synopsis

A GC method utilizing electron-capture detection is described for the measurement of certain fluorinated chloromethane and chloroethane propellants in dog blood. The lower limits of quantitation were 3.3, 10, 40, and 80 ng./nil. of blood for trichloromonofluoroniethane, dichlorodifluoromethane, trichlorotrifluoroethane, and dichlorotetrafluoroethane, respectively. These fluorocarbons were determined simultaneously in the arterial and venous blood of anesthetized male and female dogs following administration (by inhalation) of an aerosol mixture containing 25% (w/w) of each propellant. Trichloromonofluoromethane demonstrated the highest blood levels and declined slowly, whereas dichlorodifluoromethane and dichlorotetrafluoroethane showed lower blood concentrations and declined more rapidly. Trichlorotrifluoroethane declined a t a rate that was intermediate between trichloromonofluoroniethane and dichlorodifluoromethane.