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Determination of drugs and drug-like compounds in different samples with direct analysis in real time mass spectrometry

✍ Scribed by Elena S. Chernetsova; Gertrud E. Morlock

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
145 KB
Volume
30
Category
Article
ISSN
0277-7037

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✦ Synopsis

Abstract

Direct analysis in real time (DART), a relatively new ionization source for mass spectrometry, ionizes small‐molecule components from different kinds of samples without any sample preparation and chromatographic separation. The current paper reviews the published data available on the determination of drugs and drug‐like compounds in different matrices with DART‐MS, including identification and quantitation issues. Parameters that affect ionization efficiency and mass spectra composition are also discussed. © 2011 Wiley Periodicals, Inc., Mass Spec Rev 30:875–883, 2011

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