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Determination of DMP 728, a IIbIIIa receptor antagonist, in rat and dog plasma by high-performance liquid chromatography with fluorimetric detection

โœ Scribed by S.T. Wu; H.F. Stampfli; C.M. Banks; T.A. Emm; R.P. Kapil; P.K. Padovani; W.M. Lee Jr.; S.-M. Huang

Publisher
Elsevier Science
Year
1994
Weight
335 KB
Volume
657
Category
Article
ISSN
0378-4347

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Simultaneous determination of YM928, a n
Simultaneous determination of YM928, a novel noncompetitive AMPA receptor antagonist, and its demethylated metabolite in rat, dog and monkey plasma by high-performance liquid chromatography with ultraviolet detection
โœ Kota Kato; Kiyoshi Noguchi; Toshiko Aoki; Yoshiaki Soeishi; Hidetaka Kamimura ๐Ÿ“‚ Article ๐Ÿ“… 2006 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 285 KB ๐Ÿ‘ 2 views

A specific HPLC method for the simultaneous determination of YM928, a novel noncompetitive AMPA receptor antagonist, and its demethylated metabolite (YM-58875) in rat, dog and monkey plasma was developed and validated. The method utilized multiple-step liquid-liquid extraction followed by a reversed