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Determination of dextromethorphan and its metabolites in plasma by dual column liquid chromatography and fluorimetric detection

✍ Scribed by Margareta Johansson; Christine Svensson


Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
598 KB
Volume
6
Category
Article
ISSN
0731-7085

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A method for the determination of bupropion and its three major basic metabolites in plasma is described. Following an extraction from alkaline plasma into 1.5% v/v isoamyl alcohol in n-heptane, a portion of the acid-backwashed extract was injected onto a column packed with trimethylsilyl reverse-ph