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Determination of cyclophosphamide metabolites by gas chromatography and thermionic specific detection interindividual differences in hepatic biotransformation of cyclophosphamide in man in vitro

โœ Scribed by P.J.M. Sessink; W.H.J. Vaes; P.H.H. van den Broek; J. Noordhoek; R.P. Bos

Publisher
Elsevier Science
Year
1995
Weight
498 KB
Volume
673
Category
Article
ISSN
0378-4347

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A method is described for the determination of the antitumour drug cyclophosphamide and six stable metabolites in plasma of cancer patients, namely dechloroethyl-cyclophosphamide, 4-keto-cyclophosphamiide, carboxyphosphamide, alcophosphamide, nor-nitrogen mustard and the N-chloroethyl-l,3-oxazolidin