Determination of colloidal electrolytes: conductimetric titration of hydroxyzine hydrochloride with ammonium molybdate
✍ Scribed by Ryszard Mikulski; Brunon Dembiński
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 228 KB
- Volume
- 272
- Category
- Article
- ISSN
- 0003-2670
No coin nor oath required. For personal study only.
✦ Synopsis
A solution contammg l-30 mg of hydroxyzme hydrochlonde can be titrated conductlmetncally wth ammomum molybdate The proposed method was checked by the determmatlon of hydroxyzme hydrochloride m a Hydroxyzmum preparation Keywords Conductlmetry, Tltnmetry, Colloidal electrolytes, Hydroxyzme hydrochloride, Pharmaceuticals Colloidal electrolytes are widely used m the pharmaceuttcal industry, which has led to the need for methods for the determmatlon of such compounds, especially when present m low concentrations Hydroxyzme hydrochloride (2-{2-[4-(p-chloro-cr-phenylbenzylj-l-plperazmyllethoxy} ethanol dlhydrochlonde, apphed, e g , m Atarax, Hydroxyzmum, Masmoran or Vlstarll preparations) IS used as a psychotropic drug that acts on the nervous system, lessening Its lrrltablhty An aqueous solution of hydroxyzme hydrochlonde exhibits colloidal properties and forms a poorly soluble compound wth ammomum molybdate Ammomum molybdate was used earher wth success to determme dodecylqumolmmm bromide by amperometrx titration [ll Gravnnetry, tltrnnetxy and some instrumental techmques (spectrophotometry, polarography, amperometry, potentlometry) are the methods most often used to determine psychotropic drugs [2-61