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Determination of clozapine and desmethylclozapine in human plasma by high-performance liquid chromatography with ultraviolet detection

โœ Scribed by Ming-Cheng Chung; Shih-Ku Lin; Wen-Ho Chang; Michael W. Jann


Publisher
Elsevier Science
Year
1993
Weight
468 KB
Volume
613
Category
Article
ISSN
0378-4347

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Measurement of clozapine and norclozapin
โœ P. T. McCarthy; S. Hughes; C. Paton ๐Ÿ“‚ Article ๐Ÿ“… 1995 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 579 KB

A simple method for the measurement of clozapine and its A'-desmethyl metabolite in human plasma or serum by high performance liquid chromatography is described. An internal standard (aqueous nortriptyline, 4 mg/L) (50 pL) and Tris buffer (2 mol/L, pH 10.6) (100 pL) are added to plasma/serum (200 pL