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Determination of bromazepam in blood by electron-capture GLC and of its major urinary metabolites by differential pulse polarography

โœ Scribed by J. Arthur F. De Silva; Ihor Bekersky; Marvin A. Brooks; Robert E. Weinfeld; William Glover; Carl V. Puglisi


Publisher
John Wiley and Sons
Year
1974
Tongue
English
Weight
615 KB
Volume
63
Category
Article
ISSN
0022-3549

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This report presents data to demonstrate the clinical utility of a previously published electron-capture GLC assay in the measurement of blood levels of 7-chloro-1,3-dihydro-5-(2'-chlorophenyl)-2H -1,4-benzodiazepin-2-one in humans following a single oral 4-mg dose. It also describes a differential

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A sensitive and specific electron-capture GLC assay was developed for the determination of clonazepam and flunitrazepam (two members of the 7-nitro-1,4-benzodiazepin-2-one class of compounds) in blood and urine. The assay for clonazepam uses flunitrazepam as a reference standard and vice versa. The