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Determination of Bis(9)-(−)-Meptazinol, a bis-ligand for Alzheimer's disease, in rat plasma by liquid chromatography–tandem mass spectrometry: Application to pharmacokinetics study

✍ Scribed by Xin-xing Ge; Xiao-lin Wang; Pan Jiang; Ying Xie; Tao Jiang; Zheng-xing Rong; Qi-zhi Zhang; Qiong Xie; Zhui-bai Qiu; Hao Wang; Hong-zhuan Chen

Book ID: 116620681
Publisher: Elsevier Science
Year: 2012
Tongue: English
Weight: 421 KB
Volume: 881-882
Category: Article
ISSN: 1873-376X
DOI: 10.1016/j.jchromb.2011.12.010

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## Abstract A rapid and sensitive LC/MS/MS assay was developed and validated for the determination of clopidogrel in human plasma. Clopidogrel was extracted by single liquid–liquid extraction with pentane, and chromatographic separations were achieved on a C~18~ column. The method was validated to