Determination of bioavailability and systemically available fractions of drugs undergoing reversible metabolism: Application to 4-amino-5-chloro-2-[2-(methylsulfinyl)ethoxy]-N-[2-(diethylamino)ethyl]benzamide and Its Sulfide and sulfone metabolites in rats

Pharmacokinetics and metabolic interconv

Pharmacokinetics and metabolic interconversion of intravenous 4-amino-5-chloro-2-[(methylsulfinyl)ethoxy]-N-[2-(diethylamino)ethyl]benzamideand its sulfide and sulfone metabolites in rats

✍ Be-Sheng Kuo; James C. Poole; Kin-Kai Hwang; Haiyung Cheng 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 495 KB

The pharmacokinetics of a new 5-hydroxytryptamine (5HT,) receptor antagonist, 4-amino-5-chloro-2-[(methylsulfinyl)ethoxy]-N-[2-(diethylamino)ethyl]benzamide (ML-1035, l ) , and its sulfone and sulfide metabotiies were examined in 12 rats. Each of these compounds (25.4 fimol/kg) was administered to r