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Determination of benzalkonium chloride in contact lens solutions by positive-ion fast atom bombardment mass spectrometry

✍ Scribed by S. Pinzauti; M. Bambagiotti-Alberti; G. Moneti; E. La Porta; S.A. Coran; F.F. Vincieri; P. Gratteri

Book ID
103911215
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
417 KB
Volume
7
Category
Article
ISSN
0731-7085

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✦ Synopsis

Under positive-ion fast atom bombardment (FAB) mass spectrometric conditions, benzalkonium chloride (BAK) afforded intense peaks at m/z 304 and 332, corresponding to the intact cations [M--Cl]+ of C12 and C14 homologues, respectively. The use of benzethonium chloride as an internal standard and thioglycerol as a FAB matrix allowed the direct and specific determination of the BAK content (0.004-0.020%) in commercial hard contact lens solutions through the individual assay of the two alkyl homologues. A linear relationship between the homologue concentration and the peak-area ratio was observed over the concentration range 3-180 micrograms ml-1.

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