Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase (NOS), may be related to reduced biosynthesis of nitric oxide in diseases associated with accelerated atherosclerosis. The closely related compound symmetric dimethylarginine (SDMA) does not inhibit NOS, but may com
Determination of asymmetric and symmetric dimethylarginines in plasma of hyperhomocysteinemic subjects
โ Scribed by R. Paroni; I. Fermo; P. Fiorina; G. Cighetti
- Publisher
- Springer
- Year
- 2005
- Tongue
- English
- Weight
- 91 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0939-4451
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๐ SIMILAR VOLUMES
## Background: Nitric oxide (no) synthesis is inhibited by the adma that accumulates in the plasma of patients with renal failure; however, the concentration of sdma also is enhanced. therefore, it has been hypothesized that adma and sdma may contribute to hypertension in these patients. ## Method
## Abstract Arginine (ARG) is a substrate for endogenous nitric oxide (NO) production whereas its metabolite, asymmetric dimethylarginine (ADMA), acts as an inhibitor. Sufficient NO production is essential for cardiovascular key functions, thus elevated concentration levels of ADMA are related to a