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Determination of ampicillin and amoxycillin by flow injection chemiluminescence method based on their enhancing effects on the luminol–periodate reaction

✍ Scribed by Yinhuan Li; Yuhai Tang; Hong Yao; Junmei Fu


Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
86 KB
Volume
18
Category
Article
ISSN
1522-7235

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✦ Synopsis


Abstract

In this work, a new flow injection chemiluminescence method is described for the determination of ampicillin and amoxycillin. The method is based on the strong enhancing effects of these antibiotics on the luminol–periodate reaction. The present method allows the measurements of ampicillin in the range 0.02–1.0 mg/L range and amoxycillin in the range 0.1–10.0 mg/L range with the relative standard deviations within 0.8–2.0%. The sampling frequency was calculated about 90/h. The method was successfully applied to the determination of ampicillin and amoxycillin in pharmaceutical preparations. A brief discussion on the possible chemiluminescence reaction mechanism is presented. Copyright © 2003 John Wiley & Sons, Ltd.


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