Although gas chromatography/mass spectrometry (GC/MS) is the most powerful technique for analysing cocaine and its hydrolysis products (benzoylecgonine, ecgonine methyl ester and ecgonine) in urine, the sample pretreatment required is rather laborious and involves a large number of steps. This paper
✦ LIBER ✦
Determination of amphetamine and methamphetamine enantiomers by chiral derivatization and gas chromatography–mass spectrometry as a test case for an automated sample preparation system
✍ Scribed by Dr. Hans-Jürgen P. Sievert
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 535 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0899-0042
No coin nor oath required. For personal study only.
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Polar analytes that possess protic functional groups have often been treated with alkyl chloroformates to decrease their polarity and increase their volatility prior to gas chromatography-mass spectrometry analysis. This derivatization reaction has two distinct advantages. It proceeds smoothly in aq