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Determination of amino acids in human plasma by liquid chromatography with postcolumn ninhydrin derivatization using a hydroxyapatite cartridge for precolumn deproteination

✍ Scribed by Hiroshi Iwase; Shinichi Ozawa; Makiko Ikuta; Ichiro Ono

Publisher
Elsevier Science
Year
1995
Weight
562 KB
Volume
663
Category
Article
ISSN
0378-4347

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## Abstract A rapid and sensitive HPLC enantioselective method with fluorescence detection was developed to determine (βˆ’)‐(__R__) and (+)‐(__S__) enantiomers of the metabolites of citalopram, demethyl‐ and didemethyl‐citalopram in plasma and brain tissue. This assay involves pre‐column chiral deriv