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Determination of absolute configuration of ketamine enantiomers by HPLC-CD-UV technique

✍ Scribed by András Gergely; Ferenc Zsila; Péter Horváth; György Szász

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 127 KB
Volume: 11
Category: Article
ISSN: 0899-0042
DOI: 10.1002/(sici)1520-636x(1999)11:10<741::aid-chir1>3.0.co;2-2

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✦ Synopsis

Recognizing that the stereochemical structure of NMDA receptor antagonist ketamine provides valuable data about the relationship between its conformation and absolute configuration by CD-UV analysis, a method for the identification of ketamine enantiomers is proposed which avoids the need for authentic samples of the enantiomers. The ketamine enantiomers were separated by HPLC using Chiralcel OJ stationary phase. The in situ registration of CD and UV spectra, together with the application of the octant rule for cyclohexanone derivatives, makes possible the direct assignment of the eluted ketamine enantiomers. Chirality 11: 741-744, 1999.

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