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Determination of absolute configuration of C14−C23 fragment in symbiodinolide

✍ Scribed by Chunguang Han; Yoshi Yamano; Masaki Kita; Hiroyoshi Takamura; Daisuke Uemura

Publisher
Elsevier Science
Year
2009
Tongue
French
Weight
431 KB
Volume
50
Category
Article
ISSN
0040-4039

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✦ Synopsis

The degradation product C14ÀC23 2 was obtained using ethenolysis with the 2nd-generation Hoveyda-Grubbs catalyst from 62-membered lactone in symbiodinolide (1). The absolute configurations of three chiral centers in fragment 2 were assigned as 17R, 18R, and 21R by a combination of J-based configuration analysis and the Mosher-Riguera method.

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