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Determination of a novel epothilone D analog (AV-EPO-106) in human plasma using ultra-performance liquid chromatography–tandem mass spectrometry

✍ Scribed by Shuang-Qing Zhang; Harsha Vinnakota; Jae-Chul Jung; Paulo Carvalho; Amar G. Chittiboyina; Mitchell A. Avery; Bonnie A. Avery

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
251 KB
Volume
23
Category
Article
ISSN
0269-3879

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## Abstract A rapid, sensitive, and simple ultra‐performance liquid chromatography–tandem mass spectrometry (UPLC/MS/MS) method for the determination of udenafil and its active metabolite, DA‐8164, in human plasma and urine using sildenafil as an internal standard (IS) was developed and validated.