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Determination of a novel cognitive enhancer, X9121, and its mono N-oxide metabolite, XG696, in dog plasma by reversed-phase high-performance liquid chromatography with ultraviolet detection

✍ Scribed by Ram P Kapil; William Lee Jr.; Patricia K Padovani; Nancy Y Wong; Karsten A Holm; Gilbert N Lam


Publisher
Elsevier Science
Year
1995
Weight
386 KB
Volume
665
Category
Article
ISSN
0378-4347

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A specific HPLC method for the simultaneous determination of YM928, a novel noncompetitive AMPA receptor antagonist, and its demethylated metabolite (YM-58875) in rat, dog and monkey plasma was developed and validated. The method utilized multiple-step liquid-liquid extraction followed by a reversed