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Determination of a deuterohemin–peptide conjugate in rat plasma by liquid chromatography–tandem mass spectrometry and application to a preclinical pharmacokinetic study

✍ Scribed by Wang, Hao; Sun, Yantong; Guo, Wei; Fang, Chunxue; Fawcett, J. Paul; Li, Wei; Gao, Yin; Yang, Yan; Gu, Jingkai

Book ID: 125796457
Publisher: Elsevier Science
Year: 2014
Tongue: English
Weight: 547 KB
Volume: 98
Category: Article
ISSN: 0731-7085
DOI: 10.1016/j.jpba.2014.06.026

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## Abstract Zearalenone, a mycotoxin biosynthesized by various __Fusarium__ fungi, is widely found as a contaminant in grains and animal feeds. This study describes a rapid and sensitive LC/MS/MS assay method for the quantification of zearalenone in rat serum. The assay was validated to demonstrate