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Determination of 6-keto prostaglandin F1α and its metabolites in human plasma by LC–MS/MS

✍ Scribed by Mark Enzler; Stefan Schipp; Laurent B. Nicolas; Jasper Dingemanse; Christoph Siethoff

Book ID
116620807
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
457 KB
Volume
901
Category
Article
ISSN
1873-376X

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## Abstract The anticancer drug capecitabine and its metabolites [including the active metabolite 5‐fluorouracil (5‐FU)] display high pharmacokinetic inter‐patient variability. Such variability, which may lead to treatment failure or toxicity, could need drug concentration measurement to individual