Determination of 3,4-dimethylhippuric acid as a biological monitoring index for trimethylbenzene exposure in transfer printing workers
✍ Scribed by Yukio Fukaya; Isao Saito; Tadao Matsumoto; Yasuhiro Takeuchi; Shinkan Tokudome
- Publisher
- Springer-Verlag
- Year
- 1994
- Tongue
- English
- Weight
- 238 KB
- Volume
- 65
- Category
- Article
- ISSN
- 0340-0131
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✦ Synopsis
The relationship between exposure to 1,2,4trimethylbenzene ( 1,2,4-TMB) and urinary concentration of 3,4-dimethylhippuric acid ( 3,4-DMHA), one of its metabolites, was studied in workers involved in transfer printing Airborne TM Bs were sampled by an organic vapor monitoring badge and analyzed by capillary gas chromatography Urinary 3,4-DMHA and creatinine were analyzed under the same conditions of high-performance liquid chromatography The exposure concentration of 1,2,4-TMB among workers was around 25 ppm, the threshold limit value (TLV) The urinary concentration of 3,4-DMHA was low at the start of each shift and high at the end Exposure to the TLV ( 25 ppm) of 1,2,4-TMB results in a urinary 3,4-DMHA concentration of 410 mg/g creatinine (r = 0 897, P < 0 001) Urinary 3,4-DMHA concentration could be used as a biological monitoring index for 1,2,4-TMB exposure.