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Determination of 2-Oxohistidine by Amino Acid Analysis

โœ Scribed by Sandra A. Lewisch; Rodney L. Levine

Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
112 KB
Volume
231
Category
Article
ISSN
0003-2697

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โœฆ Synopsis

and pathologic conditions. Recent studies identified the Oxidative modification of proteins has been impliunusual amino acid, 2-oxohistidine as an oxidation cated in aging, ischemia reperfusion, carcinogenesis, product of biomolecules (Fig. 1). Thus far, two enzymes and other phenomena. Oxidation of the C-2 position of have been shown to lose specific activity concomitant the imidazole ring of histidine converts the residue to with the oxidation of a histidine residue at the active 2-oxohistidine, a novel amino acid which may serve site and formation of 2-oxohistidine. These are bovine as a marker of oxidative modification of proteins (K. erythrocyte Cu,Zn-superoxide dismutase (1,8-11) and

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