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Determinants of transhepatic cholesterol flux and their relevance for gallstone formation

โœ Scribed by Silvana Zanlungo; Attilio Rigotti

Book ID
111239045
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
195 KB
Volume
29
Category
Article
ISSN
0106-9543

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Two ATP-binding cassette (ABC) transporters, ABCG5 and ABCG8, have been proposed to limit sterol absorption and to promote biliary sterol excretion in humans. To test this hypothesis, a P1 clone containing the human ABCG5 and ABCG8 genes was used to generate transgenic mice. The transgenes were expr