Determinants of plasma uric acid

✍ Scribed by C. L. Gulbrandsen; N. E. Morton; D. C. Rao; G. G. Rhoads; A. Kagan

• Book ID: 104757449
• Publisher: Springer
• Year: 1979
• Tongue: English
• Weight: 254 KB
• Volume: 50
• Category: Article
• ISSN: 0340-6717
• DOI: 10.1007/bf00399397

✦ Synopsis

Obesity, alcohol consumption, and hematocrit provide an index of plasma uric acid, which in path analysis has a cultural heritability of 0.11 in children and 0.23 in parents, a small maternal effect, and a genetic heritability of 0.25 in both generations. Preliminary evidence for a major locus is destroyed by the omission of one exceptional child. There is no evidence against the polygenic hypothesis for hyperuricemia in the Japanese-American population studied.