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Determinants of plasma pepsinogen levels in a population at high risk for stomach cancer in venezuela

✍ Scribed by Ikuko Kato; Kazumasa Miki; Nubia Muñoz; Jorge H. Vivas; Gladys Lopez; Simon Peraza; Elsa Carillo; Denis Castro; Olga Andrade; Victor Sanchez; Elsa Cano; Hernan Ramirez; Reto Muggli; Maja Benz; Walter Oliver

Publisher
John Wiley and Sons
Year
1995
Tongue
French
Weight
774 KB
Volume
62
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

Determinants of plasma pepsinogens (PG) levels were studied in 1365 participants in a chemoprevention trial for gastric pre‐cancerous lesions being conducted in Venezuela. Gastric biopsies, plasma samples and information on smoking and dietary habits were obtained at baseline examination. Both PG‐I and PG‐II levels increased progressively with the level of Helicobacter pylori infection in gastric biopsies, resulting in no clear trend in the I/II ratio. Instead, there was a progressive decrease in the I/II ratio with increasing degrees of infiltration of polynuclear cells and monocytes, atrophy, intestinal metaplasia and the stage of pre‐cancerous lesions. The mean I/II ratios for atrophic gastritis or more advanced lesions were less than 4.0. When subjects with the I/II ratio 4 or higher were used as controls, severe reduction in the I/II ratio (<2.0) was inversely associated with tobacco consumption. This may be due to a pharmacological effect of nicotine. The severe reduction of I/II ratio was also inversely associated with fresh fruit consumption. In addition, a decreased I/II ratio was positively associated with rice/pasta and arepas (tortilla made from corn) consumption and inversely associated with plantain consumption. Possible effects of vitamins and starchy food on the development of atrophic gastritis need to be studied further. © 1995 Wiley‐Liss, Inc.

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