๐”– Bobbio Scriptorium
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Determinants of oxygen tension in normal and tumour tissues: A theoretical study

โœ Scribed by Kamales Bhaumik; Viney Kumar Jain

Book ID
104749002
Publisher
Springer Netherlands
Year
1991
Tongue
English
Weight
757 KB
Volume
18
Category
Article
ISSN
0092-0606

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โœฆ Synopsis

The partial pressure of 0, (PO,) at any point within the tissue surrounding a blood capillary is obtained through a modified version of the Erlang-Krogh model, in which the details of the intracapillary pressure profile and the axial diffusion of oxygen have been taken into consideration. The model is analytically solvable and contains only a single free parameter. A search for the major determinants of tissue 0, tension reveals that the parameters influencing the ~0, profile within the capillaries are the most sensitive factors. Experimentally obtained ~0, histograms of ,various normal and tumour tissues can be reproduced fairly accurately from the model.

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