Determinants of laminin polymerization revealed by the structure of the α5 chain amino-terminal region

✍ Scribed by Hussain, Sadaf-Ahmahni; Carafoli, Federico; Hohenester, Erhard

• Book ID: 109851701
• Publisher: Nature Publishing Group
• Year: 2011
• Tongue: English
• Weight: 980 KB
• Volume: 12
• Category: Article
• ISSN: 1469-221X
• DOI: 10.1038/embor.2011.3

✦ Synopsis

Determinants of laminin polymerization revealed by the structure of the α5 chain amino-terminal region

Laminin polymers are a key component of all basement membranes. The first crystal structure of a laminin amino-terminal domain identifies a conserved surface loop in laminin alpha chains that is involved in polymer formation.