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Deterioration in synaptic plasticity of cultured hippocampal neurons of senescence-accelerated mouse prone8

✍ Scribed by Sheng Yang; Heping Zhang; Haifa Qiao; Zhenwei Liu; Wenxia Zhou; Yongxiang Zhang

Book ID
117552055
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
160 KB
Volume
1260
Category
Article
ISSN
0531-5131

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## Abstract The early‐onset, irreversible, severe deficits of learning and memory in the senescence‐accelerated mouse (SAM)‐prone/8 (SAMP8) support its use as an animal model for human dementias of early onset. Possible implication of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) in