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Detection of virus-specific DNA and RNA base-sequences in individual cells transformed or infected by adenovirus type 2

✍ Scribed by M. H. Moar; K. W. Jones

Publisher
John Wiley and Sons
Year
1975
Tongue
French
Weight
725 KB
Volume
16
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

By means of ^3^H thymidine‐labelled adenovirus 2 DNA, adenovirus‐specific DNA sequences have been localized in individual nuclei of adenovirus 2‐ or 12‐infected cells, and adenovirus‐specific RNA sequences have been detected in the permissive cells as well as in cells transformed by adenovirus type 2. The ability to detect such specific virus RNA base‐sequences in particular, by in situ hybridization, should be useful in studying the transcriptional specificities of tumours and neoplasms.

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## Abstract Skin fibroblasts exposed to cytosine arabinoside (Ara C) were infected with either cytomegalovirus (CMV) or herpes simplex virus (HSV) type 1 and 2. Herpesvirus‐determined early antigens (HV‐EA), detected by anti‐complement immunofluorescence (ACIF), occurred primarily in the nuclei, an