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Detection of the (–SEA) double α-globin gene deletion by a simple immunologic assay for embryonic ζ-globin chains

✍ Scribed by James H. Ireland; Hong-Yuan Luo; David H. K. Chui; Berbie Chu; Juliet Yuen; Y. Edward Hsia


Book ID
102698335
Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
512 KB
Volume
44
Category
Article
ISSN
0361-8609

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Fetuses with homozygous alpha-thalassemia 1, in which the deletion of all four alpha-globin genes results in the absence of any alpha-globin chains, are severely anemic with clinical features of hydrops fetalis. Definitive diagnosis of alpha-thalassemia 1 carriers is difficult since there are few re