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Detection of the prethrombotic state due to procoagulant imbalance

✍ Scribed by P. M. Mannucci; P. L. F. Giangrande; A. Bianchi Bonomi


Book ID
114791559
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
550 KB
Volume
48
Category
Article
ISSN
0902-4441

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Patients with cirrhosis possess an imbalance in procoagulant versus anticoagulant activity due to increased factor VIII and decreased protein C. This imbalance can be detected by thrombin-generation assays performed in the presence/absence of thrombomodulin (predicate assay) that are not readily ava