✦ LIBER ✦
Detection of the granulocyte-specific antigen 3-fucosyl-N-acetyl-lactosamine on leukemic cells after neuraminidase treatment
✍ Scribed by P. A. T. Tetteroo; M. B. T Van Veer; J. F. Tromp; A. E. G. Kr von dem Borne
- Publisher
- John Wiley and Sons
- Year
- 1984
- Tongue
- French
- Weight
- 377 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0020-7136
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✦ Synopsis
Abstract
The carbohydrate antigen 3‐fucosyl‐N‐acetyl‐lactos‐amine (FAL) is expressed on human granulocytes and is detected by a monoclonal antibody B4.3. After neuraminidase treatment, this structure can also be detected on monocytes and on the cells of nearly all acute myeloid leukemia patients (38/39). It is then also present on the cells of a number of CALLA‐positive lymphatic leukemias (8/18), but not on T‐ALL and B‐ALL cells. On cells of patients with AUL, the antigen is then detected in many TdT^+^ cases, but not in TdT^−^ cases.