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Detection of the breakpoint cluster region-ABL fusion in chronic myeloid leukemia with variant Philadelphia chromosome translocations by in situ hybridization

✍ Scribed by Sabrina Tosi; Georges Cabot; Giovanni Giudici; Viviana Attuati; Paolo Morandi; Alessandro Rambaldi; Hartmut Döhner; Andrea Biondi


Book ID
113253769
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
347 KB
Volume
89
Category
Article
ISSN
0165-4608

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We report the sublocalization of the breakpoint in chromosome 22 in 33 patients with chronic myeloid leukemia (CML) who also had unusual marrow cytogenetics. In 23 patients, the leukemic clones were characterized by Philadelphia (Ph') chromosomes that arose through complex translocations that involv