Detection of the age-dependent 4977 bp deletion of mitochondrial DNA
✍ Scribed by C. Meißner; N. von Wurmb; M. Oehmichen
- Publisher
- Springer-Verlag
- Year
- 1997
- Tongue
- German
- Weight
- 79 KB
- Volume
- 110
- Category
- Article
- ISSN
- 0937-9827
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Using a polymerase chain reaction (PCR) method, we tested for the hepatic mitochondrial DNA (mtDNA) deletion in 40 hepatic tumors (28 hepatocellular carcinomas [HCCs], 9 other malignant tumors, and 3 benign tumors) and in the livers of 71 patients, including 16 pediatric patients with end-stage live
The abundance of mitochondrial DNA (mtDNA) deletions has been shown to increase with age in a number of species and may contribute to the aging process. Estimating the total mtDNA deletion load of an individual is essential in evaluating the potential physiological impact. In this study, we compared