## Communicated by Mireille Claustres Novel fluorescent oligonucleotides that contain a 3Β’ minor groove binding group (MGB) hybridize to single-stranded targets with increased sequence-specificity compared to ordinary DNA probes. This reduces non-specific probe hybridization and results in low bac
β¦ LIBER β¦
Detection of single nucleotide polymorphisms in the mannose-binding lectin gene using minor groove binder-DNA probes
β Scribed by Erna Van Hoeyveld; Frans Houtmeyers; Caroline Massonet; Leen Moens; Marc Van Ranst; N. Blanckaert; Xavier Bossuyt
- Book ID
- 113716759
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 135 KB
- Volume
- 287
- Category
- Article
- ISSN
- 0022-1759
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## Abstract The UGT1A1 Taqman MGB probe single nucleotide polymorphism (SNP) genotyping assay was developed to detect nucleotide 211 of the UDPβglucoronocyltransferase 1A1 (UGT1A1) gene. Defects in this enzyme interfere with process of conjugation of bilirubin and cause unconjugated hyperbilirubine