## Abstract ## BACKGROUND: Somatic mutations in the epidermal growth factor receptor (EGFR) kinase domain are associated with sensitivity to EGFRβtyrosine kinase inhibitors (EGFRβTKI) in patients with nonsmall cell lung cancer (NSCLC). ## METHODS: The authors tested the possibility that nucleoti
β¦ LIBER β¦
Detection of response-predicting mutations in the kinase domain of the epidermal growth factor receptor gene in cholangiocarcinomas
β Scribed by G. -Y. Gwak; J. -H. Yoon; C. M. Shin; Y. J. Ahn; J. K. Chung; Y. A. Kim; T. -Y. Kim; H. -S. Lee
- Publisher
- Springer-Verlag
- Year
- 2005
- Tongue
- English
- Weight
- 179 KB
- Volume
- 131
- Category
- Article
- ISSN
- 1432-1335
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## Abstract The presence of activating mutations within the tyrosine kinase domain of the epidermal growth factor receptor gene has been attributed to a positive response to biological therapy of lung cancer by smallβmolecular tyrosine kinase inhibitors, gefitinib and erlotinib. Among the two most