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Detection of pre-S2 and its antibody in serum from patients with fulminant type B hepatitis (FH-B)

Book ID
122460188
Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
61 KB
Volume
7
Category
Article
ISSN
0168-8278

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Hepatitis B virus (HBV) infection is the main cause of Controversial data were recently published concerning the fulminant hepatitis (FH) in several geographic areas, includassociation of hepatitis B virus (HBV) variants with fulminant ing the Mediterranean basin. 1 Traditionally the fulminant hepat

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Sera from 11 patients with fulminant hepatitis B were tested for antibodies to translation products of the pre-S1 and pre-S2 regions of hepatitis B virus of IgM, IgA and IgG classes, as well as of IgA1, IgA2 and SIgA, with solid-phase enzyme immunoassays using native viral polypeptides. Antibodies t

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The peptide which is encoded by the pre-S(2) region of hepatitis B virus DNA, the pre-S(2) antigen, was determined quantitatively by an enzyme immunoassay system employing monoclonal antibodies. The prevalence and titer of pre-S(2)Ag were 91.9% (91/99) and 10,356 2 19,053 units (mean f S.D., arbitra