Detection of Phosphomonoester Signals in Proton-Decoupled31P NMR Spectra of the Myocardium of Patients with Myocardial Hypertrophy
✍ Scribed by Wulf-Ingo Jung; Ludger Sieverding; Johannes Breuer; Oliver Schmidt; Stefan Widmaier; Michael Bunse; Franz van Erckelens; Jürgen Apitz; Guenther J. Dietze; Otto Lutz
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 76 KB
- Volume
- 133
- Category
- Article
- ISSN
- 1090-7807
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✦ Synopsis
Proton-decoupled 31P NMR spectroscopy at 1.5 T of the anterior left ventricular myocardium was used to monitor myocardial phosphate metabolism in asymptomatic patients with hypertrophic cardiomyopathy (HCM, n = 14) and aortic stenosis (AS, n = 12). In addition to the well-known phosphorus signals a phosphomonoester (PME) signal was detected at about 6.9 ppm in 7 HCM and 2 AS patients. This signal was not observed in the spectra of normal controls (n = 11). We suggest that in spectra of patients with myocardial hypertrophy the presence of a PME signal reflects alterations in myocardial glucose metabolism.