Detection of p16 hypermethylation in circulating plasma DNA of non-small cell lung cancer patients
β Scribed by Qian An; Yong Liu; Yanning Gao; Jinfeng Huang; Xiaoli Fong; Ling Li; Dechao Zhang; Shujun Cheng
- Book ID
- 117467545
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 97 KB
- Volume
- 188
- Category
- Article
- ISSN
- 0304-3835
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## Abstract The cyclinβdependent kinase inhibitor known as __p16__ (__CDK41, CDKN2, INK4A, MTS1__) has been proposed as a tumor suppressor gene on chromosome segment 9p21. We have evaluated __CDKN2__ alterations in 34 nonβsmall cell lung cancers (NSCLCs) with matched normal tissue controls and in 9
## Abstract Aberrant promoter hypermethylation of several known or putative tumor suppressor genes occurs frequently during the etiopathogenesis of lung cancer and is a promising tool for cancer detection. In the present study, promoter hypermethylation of __p16^INK4A^__ and __CDH13__ genes was inv