Detection of oncornavirus-like particles in HeLa cells. I. Fine structure and comparative morphological classification
✍ Scribed by Hans Gelderblom; Heinz Bauer; Hajime Ogura; Reinhard Wigand; Anna B. Fischer
- Publisher
- John Wiley and Sons
- Year
- 1974
- Tongue
- French
- Weight
- 743 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0020-7136
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
Oncornavirus‐like particles have been consistently observed over a period of 3 years in HeLa cells obtained from several laboratories. The particles mature by budding, in that previously fully assembled A‐type‐like particles are enveloped by the protruding cell membrane with subsequent release of the virion. When compared morphologically to B‐ and C‐type particles, distinct differences were observed; however, the HeLa particles closely resemble two primate viruses, namely the Mason‐Pfizer monkey virus and a recently discovered virus derived from human brain cells. HeLa particles demonstrate a narrow host range. Thus a new morphological group of viruses emerges that might be specific for primates.