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Detection of nonprostatic PSA in serum and nonserum samples from women

โœ Scribed by Xavier Filella; Rafael Molina; Juan Alcover; Pablo Carretero; Antonio Manuel Ballesta

Publisher
John Wiley and Sons
Year
1996
Tongue
French
Weight
342 KB
Volume
68
Category
Article
ISSN
0020-7136

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โœฆ Synopsis

Prostate-specific antigen (PSA) has been characterized as a specific prostate marker, although recent studies have suggested the existence of PSA of nonprostatic sources. We have assessed the presence of PSA by an ultrasensitive assa~y in 276 serum and nonserum samples from women. Our data show the presence of PSA in 90% of nonsewm samples, including milk secretions, breast cysts, amniotic fluids and broncho-alveolar washings. We have also detected its presence in 58% of the sera tested, although it only exceeded 0. I kg/l in 6 of the cases. We conclude that PSA can no longer be considered a specific prostate tissue marker; since the concentrations detected in women's serum are ultralow, this finding appears to interfere minimally with its value as a tumoral marker.

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