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Detection of nerve agent markers by liquid chromatography-mass spectrometry

✍ Scribed by I. A. Rodin; A. V. Braun; I. A. Anan’eva; O. A. Shpigun; E. I. Savel’eva; I. V. Rybal’chenko; S. L. Bolotov; G. M. Rodchenkov

Book ID
110212854
Publisher
SP MAIK Nauka/Interperiodica
Year
2011
Tongue
English
Weight
174 KB
Volume
66
Category
Article
ISSN
1061-9348

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## Abstract Metabolic activation of a drug leading to reactive metabolite(s) that can covalently modify proteins is considered an initial step that may lead to drug‐induced organ toxicities. Characterization of reactive metabolites is critical to designing new drug candidates with an improved toxic