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Detection of mutations in mismatch repair genes in Portuguese families with hereditary non-polyposis colorectal cancer (HNPCC) by a multi-method approach

✍ Scribed by Fidalgo, Paulo; Almeida, Maria Rosario; West, Sarah; Gaspar, Claudia; Maia, Lara; Wijnen, Juul; Albuquerque, Cristina; Curtis, Ann; Cravo, Marilia; Fodde, Riccardo

Book ID: 110024891
Publisher: Nature Publishing Group
Year: 2000
Tongue: English
Weight: 94 KB
Volume: 8
Category: Article
ISSN: 1018-4813
DOI: 10.1038/sj.ejhg.5200393

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## Abstract ## BACKGROUND Hereditary nonpolyposis colorectal carcinoma (HNPCC) significantly raises the risk of developing colorectal carcinoma (CRC) and other extracolonic tumors. It is defined by the Amsterdam Criteria and is associated with germline mutations in mismatch repair genes, primarily