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Detection of mononuclear cells expressing hepatitis B virus in peripheral blood from HBsAg positive and negative patients by in situ hybridisation

✍ Scribed by Dr. M. Hadchouel; C. Pasquinelli; J. G. Fournier; R. N. Hugon; J. Scotto; O. Bernard; C. Brechot

Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
376 KB
Volume
24
Category
Article
ISSN
0146-6615

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✦ Synopsis

In situ hybridisation was used to detect RNA of Hepatitis B virus (HBV) in peripheral mononuclear blood cells. Presence of HBV-RNA was detected in 10/17 HBsAg positive HBeAg positive patients, in S/ 18 HBsAg positive HBeAg negative patients, in 1 /3 anti-HBs positive subjects. Four control subjects were negative. The frequency o f labelled cells varied from I to 10% of mononuclear cells. These results indicate that the DNA detected so far in mononuclear blood cells may be transcriptionally active.

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