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Detection of mitochondrial DNA mutations using temporal temperature gradient gel electrophoresis

✍ Scribed by Lee-Jun C. Wong; Tian-Jian Chen; Duan-Jun Tan


Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
127 KB
Volume
25
Category
Article
ISSN
0173-0835

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Mutational analysis of 30 recurrent known mutations detects only about 58% of Hispanic cystic fibrosis (CF) chromosomes. The low mutation detection rate has greatly hindered prenatal diagnosis and carrier testing of Hispanic families who have multiple affected children with unidentified cystic fibro